Pdf effect of phaleria macrocarpa on sperm characteristics. In terms of antioxidant content, ascorbic acid, dpph free radical scavenging activities and total phenolic content were, however, the lowest in fully ripe fruit flesh. Phaleria macrocarpa is a popular medicinal plant in indonesia and has recently been introduced in malaysia in view of its commercial potential as health supplement. The purpose of this study was to determine the effects of phaleria macrocarpa pm on male fertility by assessing its effect on the sperm characteristics which included the sperm count, motility, viability and morphology.
B 4000, ogbomoso, nigeria 2department of biomedical science, ladoke akintola university of technology, p. The insoluble matter was washed with boiling water until the final filtrate was free from acid. Meanwhile, chloroform extracts of leaves and fruits demonstrated potent antityrosinase activities as compared to a wellknown tyrosinase inhibitor, kojic acid. But if you want to avoid side effects, it is recommended to drink more water and reduce the dose of these blends. The main purpose of plants was as a source of food and food additive however. This study compared the conventional and nonconventional extraction methods for separating bioactive compounds from p.
In this study, the molecular mechanism of antitumor effect of fractioned extract of phaleria macrocarpa dlbs1425 in human retinoblastoma cells y79 was investigated by measuring the tumor cells viability, the assessment of population profiles of tumor cells in the cell cycle, and the mrna concentration of p16, p21, p53, cyclin d, cyclin e, and e2f. After obtaining the extract by evaporating, the extract will be mixed with the ozonated vegetable oil to add antibacterial properties. Boerl improved renal histological changes in alloxaninduced diabetic rats. This article is from iranian journal of basic medical sciences, volume 17. All parts of the fruit were reflux extracted with methanol. Empirically, it is potent in treating the hypertensive,diabetic, cancer and diuretic patients. Phaleria macrocarpa, antioxidant, antiinflammatory, cytotoxic activity background text for this section. Free radicals or reactive oxygen species have deleterious. Antioxidant activities and tyrosinase inhibition effects of. Antioxidant effects of methanolic extract ofphaleria. Pdf extraction of mangiferin from mahkota dewa phaleria. Phalerin in extract of phaleria macrocarpa fruit has activity as a sunscreen.
Functional properties of phaleria macrocarpa fruit flesh at different. Antioxidant effects of methanolic extract of phaleria macrocarpa scheff. A stunning, small tree or large shrub that is very rare in home cultivation, a real gem. Extraction of mangiferin from mahkota dewa phaleria macrocarpa using subcritical water. Effects of the methanol extracts phaleria macrocarpa scheff boerl fruits on angiotensin converting enzyme ace activity article pdf available december 2014 with 195 reads how we measure. From the fruits of phaleria macrocarpa, icariside c3 1, phalerin 2, and mangiferin 3 were isolated and their structures were identified on the basis of spectroscopic data. All structured data from the file and property namespaces is available under the creative commons cc0 license. Previous study suggested that pm had hepatoprotective effect on diabetic rat triastuti et.
The present investigation was undertaken with the purpose of developing pharmacopoeial standards for this species. Phaleria is flowering plant genus of about 20 species in the family thymelaeaceae selected species. The use of phaleria macrocarpa traditional medicine. Phaleria macrocarpa or mahkota dewa has been a unique plant because of its antioxidant. Many of these bioactivities are related to women pathological conditions.
It has a long history of ethnopharmacological usage, and the lack of information about its. Findings of this study showed that there was a significant difference in the mean value of the levels of uric acid before and after given fruit decoction of phaleria macrocarpa p0. Ethnopharmacological information revealed the utilization ofphaleria macrocarpa scheff. Phaleria macrocarpa, the gods crown ethnobotany the. Ijms free fulltext flavonoid analyses and antimicrobial.
Its use as an antineoplastic agent is to inhibit tumour growth. Keywords phaleria macrocarpa, morinda citrifolia, melastoma malabathricum, antioxidant. Phaleria macrocarpa suppress nephropathy by increasing renal. Antioxidants, phytochemicals, and cytotoxicity studies on phaleria macrocarpa scheff.
Pdf phaleria macrocarpa or mahkota dewa has been a unique plant. Pdf effects of the methanol extracts phaleria macrocarpa. Kandungan antioksidan pada beberapa bagian tanaman. Studies on the constituents from the fruits of phaleria. You can also choose from gmp, fda mahkota dewa, as well as from normal, sugar free mahkota dewa there are 14 suppliers who sells mahkota dewa on, mainly located in asia. This species is primarily propagated by using seeds. Testicular morphology of male rats exposed to phaleria. Methods phaleria macrocarpa fruit were divided into pericarp, mesocarp and seed. The effectiveness of phaleria macrocarpa and chemotherapy in. The extracts are reported for a number of valuable medicinal properties such as anticancer, antidiabetic. Pdf antioxidants, phytochemicals, and cytotoxicity. Phaleria capitata jack sri lanka, palau, malaysia, sumatra, borneo, java, philippines, sulawesi, moluccas, new guinea. It originates from papua island, indonesia and it grows in tropical areas. Aug 10, 2016 pdf phaleria macrocarpa or mahkota dewa has been a unique plant because of its antioxidant, antiinflammatory and anticancer properties.
Eighteen male adult spraque dawley rats were divided into three groups and designated as treatment 240 mgkg p. Phytochemistry and medicinal properties of phaleria. Formulation of oleozon with phaleria macrocarpa and. Its use as an antiinflammatory agent is to relieve inflammation and pain, and also as an antipyretic. Started from 0,125mgl for pmm and 0,25mgl for ppm can be used for antioxidant measurement with dpph. The free radical scavenging activity of the plant materials was. Antioxidant, antiinflammatory and cytotoxicity of phaleria.
This study is the first stage of ongoing 3 years project to isolate and quantify the antioxidant content in the fruit of phaleria macrocarpa, which possessed higher antioxidant activity than berry fruits, especially for natural. Media in category phaleria macrocarpa the following 5 files are in this category, out of 5 total. Effects of the methanol extracts phaleria macrocarpa. It has been reported that this plant has several medicinal properties including the ability to lower blood pressure, to cure hepatitis, to increase stamina, to treat cancer and to lower blood glucose harmanto 2003. Hdlce uptake, but also stimulates free cholesterol efflux from cells. Phaleria macrocarpa, commonly known as mahkota dewa is a medicinal plant that is. Us8569382b2 isolated compounds from phaleria macrocarpa. Diabetes was induced in male sprague dawley rats using alloxan 150 mgkg i. Animals had free access to standard pellet diet and mineral water. Thus, this research conducted to know antibacterial and radical scavenging activities of phaleria macrocarpa scheff. Boerl is native plants from indonesia, which has long been used as folk medicines for treatments various types of diseases such as cancer, liver disorders, heart disease, diabetes, arthritis, kidney disorders, stroke, and high blood pressure14. The protective effects of phaleria macrocarpa pm against oxidative stress in diabetic rats were investigated.
Molecules free fulltext development of phaleria macrocarpa. Phaleria macrocarpa, hyperglycemia, dyslipidemia, diabetes, cardiovascular. Originally from papua irian jaya, now spread out all over the island. One vital therapeutic approach for the treatment of type 2 diabetes mellitus is the use of agents that. Bioassayguided antidiabetic study of phaleria macrocarpa. Some of the patents are wo2009153692 a1, us20070203249 a1, cn102065879 b, ep2310027. The invention also relates to the use of said compounds, either as a single active compound or in combination, in a pharmaceutical dosage form that has antiproliferative activity of cancer cells, and its use relating to female related diseases. Introduction oxidation is an important reaction that produces free.
Phaleria macrocarpa phaleria macrocarpa is a tropical tree, which is growing more and more as an ornamental plant in gardens. One vital therapeutic approach for the treatment of type 2 diabetes mellitus is the use of agents that can decrease postprandial hyperglycaemia by inhibiting carbohydrate digesting enzymes. Phaleria macrocarpa and morinda citrifolia both powder and ethanolic extract. The present study investigated the effects of bioassayguided extract and fractions of the dried fruit pericarp of phaleria macrocarpa, a traditional antidiabetic plant, on. These two herbs will be macerated using isopropyl alcohol ipa and nhexane solvents for 5 days and stirring every 4 hours. The extraction and activity test of bioactive compounds in. It is found in tropical areas of new guinea up to 1,200 m 3,900 ft above sea level. Effect of phaleria macrocarpa on sexual function of rats saadat parhizkar1, che zairieha binti che zainudin2, mohammad aziz dollah2 abstract objectives. Phaleria macrocarpa, extraction, free radical scavenging. There was a significant effect of fruit decoction of phaleria macrocarpa to decrease the level of uric acid in elderly.
Another use is as an antiangiogenic agent to inhibit the growth of new blood. Antioxidant activities and tyrosinase inhibition effects. The extracts are reported for a number of valuable medicinal properties such as anticancer, antidiabetic, antihyperlipidemic, antiinflammatory, anti. And do not be surprised if you are after using the potion can sometimes feel sleepy and intoxicating side effects. Phaleria macrocarpa, commonly known as mahkota dewa is a medicinal plant that is indigenous to indonesia and malaysia. In vitro and in vivo effects of standardized extract and. The physical stability of lotion ow and wo from phaleria. Isolated antioxidant compounds can prevent and treat the free. Nutritional values such as ash, fiber, protein, fat, and carbohydrate contents were.
The purpose of current study was to determine the effect of phaleria macrocarpa p. The aims of this research was to discover the physical stability of extract in lotion and primary irritation test. Phaleria macrocarpa buah mahkota dewa, gods crown, pau is a dense evergreen tree, indigenous to indonesia. In order to monitor the health condition of the rats, their body weight was measured every week.
Phaleria macrocarpa, one of native indonesian plants, contains various bioactive compounds and thus possesses antioxidant, antimicrobial, or even anti cancer attributes. In the form of tea, traditional healers have for centuries used the bark, leaves and fruits of the tree against a variety of diseases and diseases. Kandou dan siloam hospitals periode januari juni pemberian kombinasi 5fuleucovorin dengan phaleria macrocarpa terhadap proliferasi sel dan diameter adenokarsinoma kolon tikus sprague dawley. Several patents have been done on phaleria macrocarpa after extensive animal and human clinical evaluation had been done. Dec 18, 2014 this page was last edited on 14 september 2017, at 22. Crown of god thrives in loose, fertile soil at an altitude of 101200 m above sea level. The record derives from tropicos data supplied on 20120418 which reports it as an accepted name record 50315226 with original publication details. The reduction seen in sperm count of motile sperm from grade 1 to grade 3 motility for rats rats treated with phaleria macrocarpa can be due to the supplemented with phaleria macrocarpa indicated increase in mounting frequency in rats of the same favorable effect of phaleria macrocarpa in exerting group. Research article open access in vitro and in vivo phaleria. Phaleria macrocarpa, one of native indonesian plants, contains various bioactive compounds and thus possesses antioxidant, antimicrobial, or even anti cancer attributes this study is the first stage of ongoing 3 years project to isolate and quantify the antioxidant content in the fruit of phaleria macrocarpa, which possessed higher antioxidant activity than berry fruits, especially for. Bioactive compounds and advanced processing technology.
Inhibition of mahkota dewa phaleria macrocarpa bioactive. The ethyl acetate and chloroform extracts of stems, leaves and fruits of phaleria macrocarpa were screened for their antioxidant capacity and tyrosinase inhibition properties. While the working solution for the commercial drug was used directly from the original. Phaleria macrocarpa fruit were divided into pericarp, mesocarp and seed. White fragrant flowers form from november to february, then they turn brown. In recent years, the utilization of certain medicinal plants as therapeutic agents has drastically increased. Review on phaleria macrocarpa pharmacological and phytochemical properties alara or1, alara ja2 and olalere oa1 1department of chemical engineering, ladoke akintola university of technology, p. Phaleria macrocarpa, one of native indonesian plants, contains various bioactive. Free radical scavenging activity from the sample was calculated according to the formula. It is a bushy rainforest plant with dark glossy green leaves to 18 long. The effectiveness of phaleria macrocarpa and chemotherapy. Mahkota dewa phaleria macrocarpa is a member of the thymelaeaceae family.
An earlier antihyperglycemic study with serial crude extracts of phaleria macrocarpa pm fruit indicated methanol extract me as the most effective. Pdf phaleria macrocarpa or mahkota dewa has been a unique plant because of its antioxidant, antiinflammatory and anticancer properties. Files are available under licenses specified on their description page. A pharmaceutical dosage form comprising an extract of phaleria macrocarpa which has antineoplastic, antiinflammatory, and antiangiogenic activity. Phaleria macrocarpa scheff boerl is a medicinal plant that originates from west papua, indonesia. The extraction and activity test of bioactive compounds in phaleria. The total phenolic content tpc, 1,1diphenyl2picrylhydrazyl dpph free radical scavenging and ferricion reducing power frap were used to evaluate their antioxidant capacity. Close related to phaleria clerodendron, phaleria octandra is a shrub or small tree found in tropical australia. Abstractobjectives this study was designed to investigate the effect of phaleria. Rats were acclimatized for 10 days and then divided into five intervention groups of five each. The phaleria macrocarpa extract was weighted using electronic balance and gf3000 and reconstitute in distilled water.
This page was last edited on 14 september 2017, at 22. Pdf phytochemistry and medicinal properties of phaleria. In general, the fruit of phaleria macrocarpa used to be used as a tea for treatment. Phytochemistry and medicinal properties of phaleria macrocarpa. Kandou dan siloam hospitals periode januari juni pemberian kombinasi 5fu.
Pdf phaleria macrocarpa, commonly known as mahkota dewa is a medicinal plant that is. Kandungan antioksidan pada beberapa bagian tanaman mahkota. In the present investigation, the methanol extract was further fractionated to obtain chloroform cf, ethyl acetate eaf, nbutanol nbf and aqueous af fractions, which were tested for antidiabetic activity. Consuming the plant directly can cause swollen, sprue, numb at tongue, fever, even unconscious. Adenokarsinoma kolon pdf profil adenokarsinoma kolon di rsup prof dr. Boerl thymelaceae is commonly known as crown of god, mahkota dewa, and pau. Phaleria macrocarpa is an indonesian endemic plant, it has been reported to have hypoglycemic activities as an inhibitor of enzyme. Boerl thymelaceae originates from papua island, indonesia and grows in tropical areas. Us8569382b2 isolated compounds from phaleria macrocarpa as.
This study aimed to evaluate the effect of phaleria macrocarpa on sperm characteristics of adult rats during 7 weeks supplementation in comparison to either testosterone hormone as positive control or distilled water as negative control. Boerl is native plants from indonesia, which has long been used as folk medicines for treatments various types of diseases such as cancer, liver disorders, heart disease, diabetes, arthritis, kidney disorders, stroke, and high blood pressure harmanto, 2003. Aprilita rinayanti universitas esa unggul 15 publications 15 citations see profile maksum radji university of indonesia 58 publications 191 citations see profile abdul. Ethanol extract of mahkota dewa phaleria macrocarpa. Effect of phaleria macrocarpa on sexual function of rats. Icariside c3 1 showed a slow vasorelaxant activity against noradrenalineinduced contraction of isolated rat aorta. Effects of the methanol extracts phaleria macrocarpascheff. The fruit of this plant is known to contain numerous different compounds that produce different bioactivities. Hdl ce uptake, but also stimulates free cholesterol efflux from cells. Effect of phaleria macrocarpa on sperm characteristics in. Antioxidants, phytochemicals, and cytotoxicity studies on. After the administration of pm fractions for two weeks the diabetic symptoms, nephropathy and renal antioxidant enzymes were evaluated. The result shows that there was an increase in caspase 3 expression in all treatment groups which were given phaleria macrocarpa extract, paclitaxelcisplatin chemotherapy, and the combination of both. A wide variety of mahkota dewa options are available to you, such as bag, box, and bottle.1404 1182 1536 1251 758 189 185 1354 1436 147 1201 543 257 436 1393 1634 396 368 445 220 1528 349 494 429 1080 62 1333 625 377 1374 193 610 1204 1061 884 943 202